TETANUS ANTITOXIN

Indications

• Post-exposure prophylaxis of tetanus in individuals with:

• Wounds that are contaminated, deep, puncture-type, or involve devitalized tissue (e.g., crush injuries, burns, frostbite).
• Inadequate or unknown vaccination history against tetanus.
• Failure to complete the primary series or uncertain immune status.

• Treatment of clinical tetanus:

• Administered in diagnosed or strongly suspected cases of tetanus to neutralize unbound tetanus toxin.

• Prophylaxis in high-risk patients:

• Such as in settings where tetanus immunoglobulin (TIG) (human-derived) is unavailable.
• May be used in developing countries where equine-derived TAT is more commonly available.